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VOLUME 8, 2007  Issue Number 3 , 390-394
DownLoad : 390-394 c_Kuttan 5.pdf
RESEARCH COMMUNICATIONS
Effect of Homeopathic Medicines on Transplanted Tumors in Mice
ES Sunila et al 390
Abstract
Ultra low doses used in homeopathic medicines are reported to have healing potential for various diseases
but their action remains controversial. In this study we have investigated the antitumour and antimetastatic
activity of selected homeopathic medicines against transplanted tumours in mice. It was found that Ruta
graveolens 200c and Hydrastis canadensis 200c significantly increased the lifespan of Ehrlich Ascites Carcinoma
and Dalton’s Lymphoma Ascites induced tumour-bearing animals by 49.7%, and 69.4% respectively. Moreover
there was 95.6% and 95.8% reduction of solid tumour volume in Ruta 200c and Hydrastis 200c treated animals
on the 31st day after tumour inoculation. Hydrastis 1M given orally significantly inhibited the growth of developed
solid tumours produced by DLA cells and increased the lifespan of tumour bearing animals. Some 9 out of 15
animals with developed tumors were completely tumour free after treatment with Hydrastis 1M. Significant
anti-metastatic activity was also found in B16F-10 melanoma-bearing animals treated with Thuja1M, Hydrastis
1M and Lycopodium1M. This was evident from the inhibition of lung tumour nodule formation, morphological
and histopathological analysis of lung and decreased levels of γ-GT in serum, a cellular marker of proliferation.
These findings support that homeopathic preparations of Ruta and Hydrastis have significant antitumour activity.
The mechanism of action of these medicines is not known at present.
Key Words: Alternative medicine - homeopathy - hydrastis – lycopodium - melanoma - metastasis - ruta - thuja
 
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