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VOLUME 10, 2009  Issue Number 4 , 565-568
DownLoad : c 565 Nayak.pdf
A Case-control Study of Roles of Diet in Colorectal Carcinoma in a South Indian Population
Sandeep P Nayak et al
Introduction: The worldwide incidence of colorectal cancer has increased rapidly in the past few decades
and dietary habits have been implicated in the cause. Though the Indian diet varies substantially from western
diet, there has not been detailed studies on any association. Materials and Methods: This is hospital based case
control study enrolling 108 cases and 324 controls, all hailing from the Malabar region of Kerala, India. The
subjects were interviewed using food frequency questionnaires for commonly consumed dietary items in the
region. Results: A strong association was found between colorectal cancer and tapioca (OR=2.7 p=0.001), beef
(OR=4.25, p=0.000) and pungent spices (OR=9.62, p=0.018). Fruits and vegetables a showed strong inverse
association (OR= 0.15 p=0.002). Fish consumption on a daily basis showed a 25% reduction in risk on univariate
analysis. Heavy consumption of sugar (OR=2.80) and tobacco use (OR=8.79) showed significant high risk.
Conclusions: There is strong evidence from our study that intake of beef, refined carbohydrates and tobacco
can promote colorectal cancer. Our study has also thrown light on some of the other commonly consumed items,
like tapioca and spices which have positive associations. These are commonly consumed in Malabar region of
Kerala. A cohort study is now needed to confirm our findings.
Key Words: Colorectal cancer - risk factors - red meat - smoking - prevention - vegetables - tea
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