Ellagic Acid Inhibits Migration and Invasion by Prostate Cancer Cell Lines
Pornsiri Pitchakarn et al
Abstract
Polyphenolic compounds from pomegranate fruit extracts (PFEs) have been reported to possess
antiproliferative, pro-apoptotic, anti-inflammatory and anti-invasion effects in prostate and other cancers.
However, the mechanisms responsible for the inhibition of cancer invasion remain to be clarified. In the
present study, we investigated anti-invasive effects of ellagic acid (EA) in androgen-independent human
(PC-3) and rat (PLS10) prostate cancer cell lines in vitro. The results indicated that non-toxic concentrations
of EA significantly inhibited the motility and invasion of cells examined in migration and invasion assays.
The EA treatment slightly decreased secretion of matrix metalloproteinase (MMP)-2 but not MMP-9 from
both cell lines. We further found that EA significantly reduced proteolytic activity of collagenase/gelatinase
secreted from the PLS-10 cell line. Collagenase IV activity was also concentration-dependently inhibited by
EA. These results demonstrated that EA has an ability to inhibit invasive potential of prostate cancer cells
through action on protease activity.
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