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VOLUME 14, 2013  Issue Number 5 , 2859-2863
DownLoad : 2859-63 4.1 Pornsiri Pitchakarn.pdf
Ellagic Acid Inhibits Migration and Invasion by Prostate Cancer Cell Lines
Pornsiri Pitchakarn et al
Polyphenolic compounds from pomegranate fruit extracts (PFEs) have been reported to possess
antiproliferative, pro-apoptotic, anti-inflammatory and anti-invasion effects in prostate and other cancers.
However, the mechanisms responsible for the inhibition of cancer invasion remain to be clarified. In the
present study, we investigated anti-invasive effects of ellagic acid (EA) in androgen-independent human
(PC-3) and rat (PLS10) prostate cancer cell lines in vitro. The results indicated that non-toxic concentrations
of EA significantly inhibited the motility and invasion of cells examined in migration and invasion assays.
The EA treatment slightly decreased secretion of matrix metalloproteinase (MMP)-2 but not MMP-9 from
both cell lines. We further found that EA significantly reduced proteolytic activity of collagenase/gelatinase
secreted from the PLS-10 cell line. Collagenase IV activity was also concentration-dependently inhibited by
EA. These results demonstrated that EA has an ability to inhibit invasive potential of prostate cancer cells
through action on protease activity.
Key Words: Ellagic acid - cancer - invasion - migration - metastasis
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