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VOLUME 14, 2013  Issue Number 10 , 5753-5759
DownLoad : 5753-5759 6.17 Partha Basu.pdf
RESEARCH ARTICLE
Clearance of Cervical Human Papillomavirus Infection by Topical Application of Curcumin and Curcumin Containing Polyherbal Cream: A Phase II Randomized Controlled Study
Partha Basu et al
Abstract
Curcumin and curcumin containing polyherbal preparations have demonstrated anti-microbial and antiviral
properties in pre-clinical studies. Till date no therapeutic intervention has been proved to be effective and
safe in clearing established cervical human papillomavirus (HPV) infection. The present study evaluated the
efficacy of Basant polyherbal vaginal cream (containing extracts of curcumin, reetha, amla and aloe vera) and
of curcumin vaginal capsules to eliminate HPV infection from cervix. Women were screened by Pap smear and
HPV DNA test by PCR. HPV positive women without high grade cervical neoplasias (N=287) were randomized
to four intervention arms to be treated with vaginal Basant cream, vaginal placebo cream, curcumin vaginal
capsules and placebo vaginal capsules respectively. All subjects were instructed to use one application of the
assigned formulation daily for 30 consecutive days except during menstruation and recalled within seven days
of the last application for repeat HPV test, cytology and colposcopy. HPV clearance rate in Basant arm (87.7%)
was significantly higher than the combined placebo arms (73.3%). Curcumin caused higher rate of clearance
(81.3%) than placebo though the difference was not statistically significant. Vaginal irritation and itching, mostly
mild to moderate, was significantly higher after Basant application. No serious adverse events were noted.
Key Words: Cervical cancer - human papillomavirus (HPV) - clearance - curcumin - polyherbal cream
 
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